Andreas Heine Selected Research

queuine tRNA-ribosyltransferase

1/2022	19F-NMR Unveils the Ligand-Induced Conformation of a Catalytically Inactive Twisted Homodimer of tRNA-Guanine Transglycosylase.
10/2021	Unraveling a Ligand-Induced Twist of a Homodimeric Enzyme by Pulsed Electron-Electron Double Resonance.
1/2021	Targeting a Cryptic Pocket in a Protein-Protein Contact by Disulfide-Induced Rupture of a Homodimeric Interface.
1/2018	Swapping Interface Contacts in the Homodimeric tRNA-Guanine Transglycosylase: An Option for Functional Regulation.
1/2017	Soaking suggests "alternative facts": Only co-crystallization discloses major ligand-induced interface rearrangements of a homodimeric tRNA-binding protein indicating a novel mode-of-inhibition.
1/2015	Replacement of water molecules in a phosphate binding site by furanoside-appended lin-benzoguanine ligands of tRNA-guanine transglycosylase (TGT).
9/2013	High-affinity inhibitors of Zymomonas mobilis tRNA-guanine transglycosylase through convergent optimization.
12/2009	How to replace the residual solvation shell of polar active site residues to achieve nanomolar inhibition of tRNA-guanine transglycosylase.
3/2009	Crystal structure analysis and in silico pKa calculations suggest strong pKa shifts of ligands as driving force for high-affinity binding to TGT.

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Andreas Heine Research Topics

Disease

11	Bacillary Dysentery (Shigellosis) 01/2022 - 03/2009
3	Foodborne Diseases 01/2015 - 07/2012
2	Multiple Sclerosis 01/2022 - 01/2018
2	Rupture 01/2021 - 10/2006
2	Diabetes Complications 01/2017 - 05/2007
1	Breast Neoplasms (Breast Cancer) 01/2022
1	Hemorrhage 01/2020
1	Phenylketonurias (Phenylketonuria) 01/2018
1	Osteoarthritis 01/2016
1	Dysentery 07/2007
1	Infections 07/2007
1	Glaucoma 01/2004
1	Neoplasms (Cancer) 09/2003

Drug/Important Bio-Agent (IBA)

10	EnzymesIBA 01/2022 - 07/2007
9	queuine tRNA-ribosyltransferaseIBA 01/2022 - 03/2009
3	LigandsIBA 10/2021 - 10/2006
2	Proteins (Proteins, Gene)FDA Link 01/2021 - 03/2009
2	Transfer RNA (tRNA)IBA 01/2018 - 09/2013
2	Aldehyde Reductase (Aldose Reductase)IBA 01/2017 - 05/2007
2	Pharmaceutical PreparationsIBA 01/2015 - 09/2013
1	DisulfidesIBA 01/2021
1	AnticoagulantsIBA 01/2020
1	Factor XIII (Coagulation Factor XIII)IBA 01/2020
1	Thrombin FDA Link 01/2020
1	sapropterin (tetrahydrobiopterin)FDA Link 01/2018
1	Serine Proteases (Serine Protease)IBA 01/2016
1	matriptaseIBA 01/2016
1	Shiga Toxin (Shigella Toxin)IBA 07/2012
1	Glucose (Dextrose)FDA LinkGeneric 05/2007
1	polyolIBA 05/2007
1	Peptides (Polypeptides)IBA 10/2006
1	zopolrestatIBA 10/2006
1	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 01/2004
1	PeptidomimeticsIBA 09/2003
1	Integrin alphaVbeta3IBA 09/2003

Therapy/Procedure

4	Therapeutics 01/2022 - 09/2003
2	Drug Therapy (Chemotherapy) 11/2020 - 01/2017
1	Immunotherapy 09/2003